| He was elected the 1st Most Desirable Men Of India for the year 2013 by The Times of India. |
| Is a huge fan of Sachin Tendulkar. |
| Is a huge fan of his father Superstar Krishna and Senior actor Nandamuri Taraka RamaRao. |
| He joined Farhan Akhtar's MARD campaign by supporting the cause and has also lent his voice to the poem written in Telugu. |
| Has won Seven Nandi Awards in which 3 for the Best Actor, 3 for Best Actor in Special Jury and 1 for Best Male Debut. |
| Has won 3 CineMAA awards for the Best Actor Category, which is the highest of any actor to date. |
| One of the few actors in Indian Film Industry who never did a remake in his career. |
| Tamil Actors Suriya, Karthi and Vaibhav (Mankatha, Goa Fame) are his childhood School Friends. |
| Mahesh's childhood was spent mostly in Madras under the care of his maternal grandmother, Smt. Durgamma, and the rest of his family. |
| Is very close to his family, especially to his brother Ramesh Babu. |
| He was voted the 2nd Most Desirable Man for the year 2012 by The Times of India. |
| Father of Gautam Krishna (born on 31 August 2006) and Sitara (born on 20 July 2012). |
| Met his wife Namrata Shirodkar on the set of his film "Vamsi". |
| He was voted the 5th Most Desirable Men for the year 2011 by The Times of India. |
| Brother of Ramesh Babu Ghattamaneni and Manjula Ghattamaneni. |
| Son of the Legendary Telugu Movie Actor Krishna Ghattamaneni. |